Clin Surg | Volume 8, Issue 1 | Research Article | Open Access

Site-Specific Response of Bone Tissue to Ovariectomy in a Rabbit Model

Feng N, Zhang Y and Li Y*

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University, China

*Correspondance to: Yunfeng Li 

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Objective: To explore the changes of bone mass and bone mineral density in different bones of New Zealand female rabbits after bilateral ovariectomy. Materials and Methods: Twenty female New Zealand rabbits were included and randomly divided into two groups: bilateral ovariectomy or sham operation. Six months after operation, the rabbits were sacrificed and the bone samples of parietal bone, maxilla, mandible, vertebrae, tibia and femur were collected. X-ray, Micro-CT, histology, biomechanical testing and inorganic substances detection were used to evaluate the changes of bone tissue at different sites. Results: Compared to control, long bones and vertebrae showed significantly decreased bone density, and inorganic substance. BV/TV of the femur decreased by 48.5%, the vertebrae decreased by 45.7%, and the tibia decreased by 32.5%. The inorganic substance in femur decreased by 30.8%, that in tibia decreased by 30.3%, and that invertebrae decreased by 22.0%. Biomechanical results also showed the most decreased mechanical property of long bone and vertebrae, while the parietal bone and jaw bone showed no significant change. Conclusion: Six months after ovariectomy in a rabbit model, the long bone and vertebrae showed the most loss of bone mass, bone mineral density and mechanical property, while the parietal bone, maxilla and mandible showed no significant change.


Feng N, Zhang Y, Li Y. Site-Specific Response of Bone Tissue to Ovariectomy in a Rabbit Model. Clin Surg. 2023; 8: 3614..

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