Incidence of Chronic Kidney Disease after Liver Transplantation in a Chinese Cohort

Jiang-Chen Peng, Ming-Li Zhu, Zheng-Yu He, Yu-Xiao Deng and Yuan Gao

Department of Critical Care, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China

^*Correspondance to: Yuan Gao 

 PDF  Full Text DOI: 10.25107/2474-1647.2627

Abstract

Background: Kidney dysfunction frequently occurred after Orthotopic Liver Transplantation (OLT). Chronic Renal Disease (CKD) is a complicated problem and is associated with increased mortality. The aim of this study is to find the risk factors for the incidence of CKD at 1 year after OLT in China. Methods: From January 2017 to December 2017, we retrospectively assessed 292 recipients in our single center. Chronic renal failure was defined as estimated Glomerular Filtration Rate (eGFR) <60 mL/min/1.73 m2 for 3 months, regardless of the presence or absence of structural kidney damage. Cox proportional hazard model was used to identify the factors to the incidence of CKD after liver transplantations. Kaplan-Meier plots with log-rank test were presented to evaluate patient survival time in those with and without CKD. Results: With a median follow-up of 17.4 months, 55 patients developed CKD after liver transplantations, representing18.8% of the cohort. The cox-regression model showed that recipients age (OR=1.093, P<0.01), Acute Kidney Injury (AKI) (OR=1.496, P<0.01) and baseline eGFR (OR=1.939, P<0.01) were significantly associated with the development of post-transplant CKD at 1 year. Recipient survival at 1 year was significantly worse in recipients with CKD compared to those without CKD (P<0.01). Conclusion: Our findings suggested that age, AKI and baseline eGFR was associated with the incidence of CKD 1 year after OLT in a Chinese cohort. Recipients with CKD were associated with worse survival.

Keywords

Liver transplantation; Chronic kidney disease; Risk factor; Survival

Cite the article

Peng J-C, Zhu M-L, He Z-Y, Deng Y-X, Gao Y. Incidence of Chronic Kidney Disease after Liver Transplantation in a Chinese Cohort. Clin Surg. 2019; 4: 2627..