Journal Basic Info
- Impact Factor: 1.995**
- H-Index: 8
- ISSN: 2474-1647
- DOI: 10.25107/2474-1647
Major Scope
- Vascular Surgery
- Oral and Maxillofacial Surgery
- Emergency Surgery
- Thoracic Surgery
- Otolaryngology - Head and Neck Surgery
- Pediatric Surgery
- Neurological Surgery
- Gynecological Surgery
Abstract
Citation: Clin Surg. 2019;4(1):2561.Research Article | Open Access
Neuroendocrine Tumors of the Gallbladder: Clinical Features, Diagnosis and Treatment
Chunyuan Niu, Shupeng Wang, Qingchun Guan, Xuekang Ren, Bai Ji and Yahui Liu
Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, China
These authors contributed equally to this manuscript
PDF Full Text DOI: 10.25107/2474-1647.2561
Abstract
Aim and Background: The unique heterogeneous tumor originating from the neuroendocrine cells and the peptide-capable neurons is defined as the Gallbladder Neuroendocrine Neoplasm (GBNEN). GB-NEN accounts for only 0.5% of all Neuroendocrine Tumors (NETs) and 2.1% of all gallbladder tumors. The aim of this study is to present an up-to-date review of clinical features, diagnosis, and treatment of neuroendocrine tumors of the gallbladder. Methods: A systematic literature search was performed using leading medical journal citation databases (including PubMed, Wiley Online Library and Springer Link Science) in order to identify all pertinent studies published. Results: At present, the pathogenesis of GB-NEN is not clear, and furthermore, the typical clinical manifestations are lacking specificity, particularly as seen in the laboratory examinations. Additionally, the imaging examination provides difficulty in distinguishing GB-NEN from other gallbladder diseases. Even though treatment, like chemo radiotherapy helps to prolong progressionfree survival, surgery is the best option. Since the disease is rarely seen in clinical practice, only a few studies are available for review. Conclusion: GB-NEN is a relatively rare gallbladder lesion and is often reported as a case study. Therefore, early detection, correct diagnosis and reasonable treatment of such tumors will aid in prolonging the quality of life of patients.
Keywords
Neuroendocrine tumor; Gallbladder; Pathological classification; Clinical features; Diagnosis
Cite the article
Niu C, Wang S, Guan Q, Ren X, Ji B, Liu Y. Neuroendocrine Tumors of the Gallbladder: Clinical Features, Diagnosis and Treatment. Clin Surg. 2019; 4: 2561..
