Dong Chu1,2, Jia-Yi Li3, Guang-Min Zhang1, Kai-Jie Sun1, Wei-Gen Xiong4, Qing-Quan Li1, Hong-Wei Fan5* and Ying-Bin Li1*
1Department of Neurosurgery, The Second Affiliated Hospital of Nanjing Medical University, China
2Xi’An International Medical Center Hospital, China
3The School of Public Health, Nanjing Medical University, China
4School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, China
5Department of Clinical Pharmacology Lab, Nanjing First Hospital, Nanjing Medical University, China
Background: Risk factors analysis affecting the prognosis of Ruptured Intracranial Aneurysms (RIA) patients is important to improve their clinical prognosis. The aim of this study was to investigate the risk factors affecting the prognosis of patients with RIA treated with interventional embolization. Methods: Retrospective analysis of 123 patients with RIA treated by interventional embolization at the second affiliated Hospital of Nanjing Medical University from January 2016 to January 2022 were selected for the study. Patient admission general information, aneurysm factors, surgical factors, postoperative factors were collected from cerebrovascular images and medical records. Identification of independent risk factors affecting the prognosis of patients with interventional RIA using chi-square test and binary multifactorial logistic regression analysis. Results: Of the 123 RIA patients, 43 were male and 80 were female, with an overall mean age of 62.43 ± 10.45 years, and the results were followed up from 3 months to 2 years. Based on the mRS score, 81 (65.9%) RIA patients had a good prognosis (mRS score 0-2) and 42 (34.1%) had a poor prognosis (mRS score 3-6). On univariate analysis, patient age, history of diabetes mellitus, smoking, alcohol consumption, Hunt-Hess (HH) score, Fisher score, regularity of RIA morphology, intraoperative use of stent-assisted embolization, and postoperative pulmonary infection were associated with patient prognosis. Later, by binary multifactorial regression logistic analysis, history of diabetes mellitus, HH score, Fisher score, and regularity of RIA morphology were independent risk factors affecting the prognosis of RIA treated by intervention? Conclusion: The prognosis of patients with ruptured aneurysms is influenced by several factors. Patient history of diabetes mellitus, HH score, Fisher score, regularity of IA morphology were independent risk factors affecting the prognosis of interventional RIA.
Chu D, Li J-Y, Zhang G-M, Sun K-J, Xiong W-G, Li Q-Q, et al. Prognostic Factors Influencing Interventional Embolization for Ruptured Intracranial Aneurysms. Clin Surg. 2022; 7: 3571..