Journal Basic Info
- Impact Factor: 1.995**
- H-Index: 8
- ISSN: 2474-1647
- DOI: 10.25107/2474-1647
Major Scope
- Oral and Maxillofacial Surgery
- Otolaryngology - Head and Neck Surgery
- Minimally Invasive Surgery
- Urology
- Gastroenterological Surgery
- Neurological Surgery
- Bariatric Surgery
- Thoracic Surgery
Abstract
Citation: Clin Surg. 2022;7(1):3555.Review Article | Open Access
New Era of Immune Checkpoints in Advanced Gastric Cancer
Liao H, Wang Y, Li Z, Chen X and Di J*
Qinghai University, Affiliated Hospital, China
PDF Full Text DOI: 10.25107/2474-1647.3555
Abstract
Gastric Cancer (GC) is a common cancer worldwide, and immunotherapy as a new breakthrough has become one of the important anti-tumor treatment modes. Immune Checkpoint Inhibitors (ICI) mainly activates the immune system by blocking PD-1/PD-L1 and CTLA-4, which is one of the main therapeutic approaches in immunotherapy. Currently, clinical trials of immune checkpoint inhibitors have been successfully used as adjunctive therapy for resectable and unresectable in AGC. At the same time, the analysis found that the data of immune checkpoint inhibitors in the Asian population showed a statistically significant overall survival advantage over the Western population. Therefore, this review reviews the recent progress of immunocheckpoint inhibitors in neoadjuvant/ adjuvant therapy for AGC and in the late treatment of unresectable GC, and describes the significant characteristics and broad application prospects of ICI in Asian population.
Keywords
Cite the article
Liao H, Wang Y, Li Z, Chen X, Di J. New Era of Immune Checkpoints in Advanced Gastric Cancer. Clin Surg. 2022; 7: 3555.
