Fujita T and Tanaka T*
Department of Neurosurgery, Asahikawa Medical University, Asahikawa, JapanFulltext PDF
Electroencephalographic and clinical observations were made after an injection of Kainic Acid (KA) solution through a chronically implanted cannula into a unilateral Visual Cortex (VC) of freely moving and unanesthetized cats. About 1 h after the KA injection, multiple spikes started at the injected site of VC and resulted in focal seizure status. About 2 h to 3 h after the injection, each seizure propagated to the right lateral Geniculate Body (GL), Mesencephalic Reticular Formation (MRF) and left visual cortex. These seizures developed and became generalized seizure status 3 h to 12 h after the injection. During interictal period, intermittent photic stimulations were occasionally tested and photoconvulsive responses were elicited. However, photosensitivity was not constant. Only several sessions of stimulation could have elicited photo-convulsive responses and generalized seizures in each animal. Then, seizures became infrequent and subsided within 30 h. The result demonstrated that KA induced VC seizure is not only applicable to study the mechanism of secondary generalization of the VC seizure but also study the possible mechanism of photically induced seizures.
Fujita T, Tanaka T. Experimental Occipital Lobe Epilepsy in Cats: A Possible Model of Photic Epilepsy. Clin Surg. 2022; 7: 3550.