Christopher M Issa1, Brett D Hambly2, Jose Garrido-Mesa3, Geoff Watson3, Kun Tao1* and Shisan Bao1*
1Department of Pathology, Tongren Hospital, Shanghai Jiaotong University School of Medicine, China
2Department of Pathology, Royal Prince Alfred Hospital, Central Clinical School, University of Sydney, Australia
3CIBER-EHD, Department of Pharmacology, ibs. GRANADA, Centre for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento, Spain
Ulcerative colitis, a chronic disorder of the gastrointestinal tract, results in inflammation. The precise underlying mechanism is still unclear; however it is believed that immunological, genetic and environmental factors contribute to development of colonic inflammation. The Interleukin-1 (IL-1) family and IL-1 ligands are associated with acute and chronic inflammation. Recently, it has been demonstrated that IL-36α, β, γ, IL-37 and IL-38 play an important role in the initiation of inflammation in a number of organs, but the possible role of IL-36α, β, γ, and IL-38 in human colitis remains, except for IL-37, to be explored. Our data show that substantial upregulated production of IL-36α, -β, -γ, IL-37 and IL 38 in the inflamed colonic mucosa from UC occurs, compared to that from the control colon, using quantitative immunohistochemistry. Furthermore, chronic disease in these patients showed severity in both clinical presentation and histopathology score, suggesting that IL 36α, β, γ, IL-37 and IL-38 associate the severity of UC. These data may provide useful information for potential therapeutic intervention for UC patients.
Issa CM, Hambly BD, Garrido-Mesa J, Watson G, Tao K, Bao S. IL-36, 37 and 38 in Ulcerative Colitis. Clin Surg. 2022; 7: 3506..