Yue Li1, Kang Ge2 and Ru-Zhi Zhang1*
1Department of Dermatology, The Third Affiliated Hospital of Soochow University, China
2Department of Dermatology, The First Affiliated Hospital of Bengbu Medical University, China
Condylomata Acuminata (CA) is an infectious disease caused by Human papillomavirus (HPV) presenting as epidermal hyperplasia. CA is characterized by a long course of disease, easy recurrence after treatment and a potential risk for skin cancer. Traditional treatments for CA include topical remedies and surgical treatments. In addition to being painful and possible scarring, most conventional treatments are accompanied by a high rate of recurrence. And it is difficult to achieve the desired therapeutic effects with traditional treatment strategies. 5-Aminolevulinic Acid (ALA)- mediated Photodynamic Therapy (ALA-PDT) can selectively destroy CA in the epidermis and ensures a better efficacy with fewer side effects such as scarring, which is important for the anogenital region. We report here a series of 66 cases of refractory anogenital CA treated with ALAPDT combined with tretinoin and all lesions were completely cured without recurrence. We believe that ALA-PDT combined with tretinoin can be used as an efficient and safe option to treat refractory anogenital CA.
Li Y, Ge K, Zhang R-Z. Treatment of Refractory Condylomata Acuminata with 5-Aminolevulinic Acid-Photodynamic Therapy Combined with Tretinoin: Report of 66 Cases. Clin Surg. 2022; 7: 3448..