Janina Markowska1*, Anna Markowska2, Robert Jach3, Michał Michałak4 and Anna Gryboś5
1Department of Oncology and Gynecologic Oncology, Poznan University of Medical Sciences, Poland
2Department of Perinatology and Women's Health, Poznan University of Medical Sciences, Poland
3Department of Gynecological Endocrinology, Jagiellonian University Medical College, Poland
4Department of Computer Science and Statistics, Poznan Medical University, Poland
5Department of Gynecology and Obstetrics, Wroclaw Medical University, Poland
Persistent infection with highly oncogenic HPV (Human papillomavirus) is a risk factor for the development of cervical intraepithelial neoplasia and cervical cancer. The aim of the study was to assess the effect of a double cryotherapy procedure performed on the cervix accompanied by complementary pharmacotherapy with intravaginally administered drugs in cases of highly oncogenic HPV infection. Abnormal cytological examination results were found in 214 patients, of these 138 were diagnosed with ASC-US (atypical squamous cells of undetermined significance), 76 with LSIL (low-grade squamous intraepithelial neoplasia). The presence of HPV in all women was determined by RT-PCR. The presence of DNA HPV was confirmed in a total of 192 women: 116 with ASC-US (84%) and all 76 cases with LSIL. Sixty-one patients had only one type of HPV-HPV 16 was most common. In 51 women, two types of HPV were detected-most frequent were HPV 16 and 18. 80 women (over 40%) were infected with multiple types of HPV. The patients underwent the cryotherapy procedure twice and, in addition, all the women were given intravaginal therapy; Betadine (Povidone-Iodine) was applied in 158 patients and Papilocare gel in the remaining 34. A HPV eradication level of 95.5% was recorded in the Betadine group and 85% in the Papilocare gel group.
Markowska J, Markowska A, Jach R, Michałak M, Gryboś A. The Effect of Cryotherapy and Local Pharmacological Treatment on Eradication of Highly Oncogenic HPV and Lesions on the Cervix. Clin Surg. 2021; 6: 3377..