Clin Surg | Volume 6, Issue 1 | Research Article | Open Access

Splenectomy and Major Sickle Cell Syndromes in Ouagadougou: What is the Benefit for Patients after Surgery?

Ouédraogo Nabonswindé Lamoussa Marie1*, Windsouri Mamadou2, Doamba Rodrigue2, Koama Adjirata3, Coulibaly Cathérine4, Simporé Jacques5 and Traoré Si Simon6

1Department of the Surgical Pole, Saint Camille Hospital of Ouagadougou, Burkina Faso
2Department of Visceral Surgery, University Hospital Center of Tingandogo, Burkina Faso
3Department of Radiology, University Hospital Center of Bogodogo, Burkina Faso
4Department of Hematology, Saint Camille Hospital of Ouagadougou, Burkina Faso
5Department of Biomolecular and Genetic Laboratory of CERBA-LABIOGENE, Burkina Faso
6Department of Visceral Surgery, University Hospital Center of Yalgado Ouédraogo, Burkina Faso

*Correspondance to: OuĂ©draogo NabonswindĂ© Lamoussa Marie 

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Abstract

Introduction: Splenectomy in major sickle cell syndromes have specific indications. The main one is hypersplenism. The aim of our research was to study and to compare the clinical and hematological parameters pre and postoperatively. Materials and Methods: This was a retrospective cohort study with an analytical aim of splenectomy performed in patients with major sickle cell syndromes from 2010 to 2019 at two hospitals (University hospital center of Yalgado Ouédraogo and Saint Camille Hospital of Ouagadougou) in Ouagadougou. Results: In 10 years, 31 cases were collected. The mean age of the patients was 27.6 ± 2 years. A history of at least three vaso-occlusive crises per year was noted in all cases. Before splenectomy, clinical anemia was noted in all cases. Physical examination revealed painful splenomegaly in 19 cases (61.3%). Hemoglobin phenotypes were: 16 cases (SC), 10cases (SS), 5 cases (Sβ+). The average blood transfusion was 6 ± 2/person/year. Splenectomy was indicated for repeated attacks of hypersplenism in 18 cases. Twenty-nine patients underwent total splenectomy and two underwent partial splenectomy. In 40.8% of cases, splenectomy was associated with cholecystectomy. In one month postoperatively, the hematological parameters showed clear improvement with an increase in the hemoglobin level of 3.7 points (p=0.001), red blood cells (p=0.03) and platelets (p=0.02). Morbidity was 3.7% and mortality 0%. Conclusion: Splenectomy decreases the postoperative transfusion needs in the short and medium term. A good follow-up limits postoperative complications.

Keywords:

Major-sickle-cell-syndrome; Splenectomy; Hypersplenism; Ouagadougou

Citation:

Marie ONL, Mamadou W, Rodrigue D, Adjirata K, Cathérine C, Jacques S, et al. Splenectomy and Major Sickle Cell Syndromes in Ouagadougou: What is the Benefit for Patients after Surgery?. Clin Surg. 2021; 6: 3340..

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