Clin Surg | Volume 6, Issue 1 | Research Article | Open Access

The Effectiveness of Tranexamic Acid in Total Knee Arthroplasty

Eun Il Soo, Kim Doo Yeol* and Kim Jong Min

Department of Orthopedic Surgery, Good Samsun Hospital, Korea

*Correspondance to: Kim Doo Yeol 

Fulltext PDF


Purpose: To investigate the clinical results of the injection of Tranexamic Acid (TNA) into the articular cavity and/or the insertion of suction drainage, in patients undergoing total knee arthroplasty. Materials and Methods: 192 patients undergoing total knee arthroplasty for degenerative knee arthritis were assigned randomly to 3 groups: Group 1 (TNA plus suction drainage); Group 2 (TNA only); Group 3 (suction drainage only). The 26 following data were analyzed: total blood loss after operation, hidden blood loss, number of transfusions, and amount of drainage, leg swelling, wounds, and other problems. Results: The total average blood loss and number of transfusions were significantly lower in Group 2 (p<0.0001), and this group experienced no problems with wounds. The average hidden blood loss was greater in Group 2, and leg swelling increased immediately following the surgery, but the swelling diminished within six weeks. There was no significant difference in the range of knee joint motion in the three groups two months after the operation (p=0.0789). Conclusion: It is advisable to inject TNA into the articular cavity during total knee arthroplasty, and not to use suction drainage.


Soo EIl, Yeol KD, Min KJ. The Effectiveness of Tranexamic Acid in Total Knee Arthroplasty. Clin Surg. 2021; 6: 3305..

Subscribe to Our Newsletter