Journal Basic Info

  • Impact Factor: 1.995**
  • H-Index: 8
  • ISSN: 2474-1647
  • DOI: 10.25107/2474-1647
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Endocrine Surgery
  •  Gastroenterological Surgery
  •  General Surgery
  •  Gynecological Surgery
  •  Cardiovascular Surgery
  •  Obstetrics Surgery
  •  Plastic Surgery
  •  Neurological Surgery

Abstract

Citation: Clin Surg. 2021;6(1):3274.Research Article | Open Access

Satisfactory Outcome with Low Activated Clotting Time (<150 Seconds) in Extracorporeal Membrane Oxygenation

Jeong In Hong, Jinwook Hwang and Hong Ju Shin*

Department of Thoracic and Cardiovascular Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Korea

*Correspondance to: Hong Ju Shin 

 PDF  Full Text DOI: 10.25107/2474-1647.3274

Abstract

Backgrounds: Optimal anticoagulation is critical for successful extracorporeal membrane oxygenation (ECMO). Activated Clotting Time (ACT) is a widely used laboratory parameter to monitor anticoagulation. The therapeutic range of ACT is 180 s-220 s. We investigated the effect of a lower target ACT (<150 sec) during ECMO on safety and outcomes and compared it with those of a conventional target ACT (180 s-200 s). Study Design and Methods: In this retrospective study, we reviewed 72 patients treated with ECMO from March 2017 to October 2019. We included 43 patients after applying the exclusion criteria and divided them into the low ACT group (<150 s, n=14, 32.6%) and conventional ACT group (≥ 150 s, n=29, 67.4%). Results: There was no difference in the successful weaning from ECMO support (50% vs. 62.1%, p=0.452) and discharge (50% vs. 41.4%, p=0.594) rates between the groups. A patient in the conventional ACT group had intracranial hemorrhage. There was no thromboembolic complication, except in one patient where an intra-circuit thrombus was observed. Conclusion: A lower target ACT level did not increase the thromboembolic risk during ECMO management. Thus, clinicians may consider lower ACT management in patients at a high risk of hemorrhagic complications. Further randomized controlled are warranted to validate these results.

Keywords

Extracorporeal circulation; Extracorporeal cardiopulmonary resuscitation; Activated clotting time; Complication; Survival to discharge

Cite the article

Hong JI, Hwang J, Shin HJ. Satisfactory Outcome with Low Activated Clotting Time (<150 Seconds) in Extracorporeal Membrane Oxygenation. Clin Surg. 2021; 6: 3274..

Search Our Journal

Journal Indexed In

Articles in PubMed

Voice Outcomes in Laryngotracheal Stenosis: Impact of the Montgomery T-tube
 PubMed  PMC  PDF  Full Text
Sildenafil Transiently Delays Early Alveolar Bone Healing of Tooth Extraction Sockets
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

The Diagnostics and Treatment of Acute Mediastinitis - Single Institute Experiences
 Abstract  PDF  Full Text
The Diagnostic Value of sCD14-ST (Presepsin) in Acute Appendicitis
 Abstract  PDF  Full Text
View More...