Jing Wang, Dongcheng Cai, Hongxia Liu, Yuanyuan Tong and Chaoyong He*
Department of Pharmacology and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, ChinaFulltext PDF
As a leading cause of morbidity and mortality worldwide, Cardiovascular Disease (CVD) refers to a class of diseases occurring in heart or blood vessels. CVD includes several conditions such as myocardial infarction (heart attack) and heart stroke (heart failure). The fundamental pathological process underlying these conditions is atherosclerosis; a multi-process vascular lesion resulted from high blood pressure, hyperlipidemia and local chronic inflammatory response. Some of the lesions in later stage are vulnerable to rupture, trigger thrombosis and obstruct the blood flow of microvascular causing heart attack or stroke. Numerous stimuli and factors participate in the development of CVD including Platelet-Derived Growth Factor (PDGF). PDGF is synthesized, stored (in the alpha granules of platelets) and released by platelets upon activation. Other types of cells including smooth muscle cells, activated macrophages and endothelial cells also produce PDGF. PDGF exerts physiological functions by binding to corresponding receptors. PDGF/PDGFR signaling pathway plays a crucial role in the development of blood vessels and other organs as well as tissues. On the other hand, aberrant activation of PDGF/PDGFR signaling pathway drives the progression of cardiovascular diseases such as atherosclerosis, transplant arteriosclerosis, fibrosis, etc. However, the exact mechanism is not fully explored yet. Here we review the contemporary biomedical knowledge on the role of PDGF/PDGFR signaling and related mechanisms in promoting cardiovascular diseases.
Wang J, Cai D, Liu H, Tong Y, He C. PDGF/PDGFR Signaling in Cardiovascular Disease. Clin Surg. 2020; 5: 2819.