Deng Xin-Ling1, Qian Chao-Si1, Tan Gui-Ting1, Chen Xue-Yan1, Feng Li-Ying1 and Yu Ying-Hua2*
1Affiliated Tumour Hospital of Guangxi Medical University, China
2Department of Breast Surgery, Affiliated Tumour Hospital of Guangxi Medical University, China
Objective: To systematically evaluate the relationship between methylation of RASSF1A and breast cancer. And to evaluate the association of methylation of RASSF1A between breast cancer and benign breast lesions. Methods: Screen the literatures that retrieved from PubMed, Cochrane Library and Ovid. Evaluate the quality of included studies. Data analysis performed by RevMan5.3 and Stata12.0 software. Results: A total of 7 articles were included in this meta-analysis, including 1,485 samples. The results indicate that the positive rate of RASSF1A methylation have conspicuous difference between breast cancer and normal group, between breast cancer and benign breast lesion, as well. Respectively (BC vs. N, OR=4.52, 95% CI (2.02~10.10), P=0.0002; BC vs. BBL, OR=3.63, 95% CI (2.50~5.43), P=0.0002; BBL vs. N, OR=0.83, 95% CI (0.53~1.30), P=0.42). Conclusion: This meta-analysis confirms that hyper-methylation of RASSF1A is closely related to breast tumor. And it is of significance in differentiating benign breast lesions from malignant breast lesions.
RASSF1A; Methylation; Breast cancer; Benign breast lesions; Meta-Analysis
Xin-Ling D, Chao-Si Q, Gui-Ting T, Xue-Yan C, Li-Ying F, Ying-Hua Y. Association of Methylation of RASSF1A between Breast Cancer and Benign Breast Lesions: A Meta-Analysis. Clin Surg. 2020; 5: 2789..