Clin Surg | Volume 5, Issue 1 | Research Article | Open Access

High-Sensitivity C-Reactive Protein and Irisin: Comparison of Serum and Saliva Levels in MI Patients

Shadi Saghafi Khadem1, Mohammad Soukhtanloo2, Fatemeh Zeidabadi3, Toktam Moghiman4 and Samira Basir Shabestari5*

1Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Iran
2Department of Medical Biochemistry, Mashhad University of Medical Sciences, Iran
3Mashhad University of Medical Sciences, Iran
4Atherosclerosis Prevention Research Center, Mashhad University of Medical Sciences, Iran
5Department of Oral Medicine, School of Dentistry, Iran University of Medical Sciences, Iran

*Correspondance to: Samira Basir Shabestari 

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Objective: Cardiovascular diseases are the main cause of mortality worldwide. Despite the importance of early detection and advancements in the field of medicine, one third of the Myocardial Infarction (MI) cases remain undiagnosed. Biomarkers are a reflection of the physiologic function and pathologic changes in the body. Saliva is a refined plasma and given the benefits of its collection and storage, it can replace blood to facilitate and accelerate the diagnosis process. We studied the correlation between serum and saliva hs-CRP and Irisin concentration in MI patients. Methods: In this case-control study 46 cases, (24 acute MI, 22 controls), the serum and saliva samples were collected and studied for hs-CRP and irisin concentration. Results: Saliva irisin was significantly higher (P=0.021) and hs-CRP level was significantly lower in the serum and saliva of the control group (P<0.001). Aging resulted in an insignificant decrease in serum but a significant increase in the saliva (P<0.001, P=0.001) of the control group. With an increase in the serum irisin and hs-CRP concentration, a slight decrease in irisin and a significant increase in hs-CRP (P<0.001) was observed in the saliva. Conclusion: The serum and saliva hs-CRP concentration had a correlation with MI. Unlike irisin, the concentration of hs-CRP in serum significantly correlated with its concentration in saliva. Since a decrease in saliva irisin concentration can also be a reliable criterion for predicting MI, it seems that both methods can be used in AMI diagnosis.


Myocardial infarction; Biomarkers; Saliva; Serum; Irisin; C-reactive protein


Khadem SS, Soukhtanloo M, Zeidabadi F, Moghiman T, Shabestari SB. High- Sensitivity C-Reactive Protein and Irisin: Comparison of Serum and Saliva Levels in MI Patients. Clin Surg. 2020; 5: 2734..

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