Aparna Gunda1, Jayanti Thumsi2, Mallika Natraj2 and Manjiri M Bakre1*
1OncoStem Diagnostics Private Limited, Raja Ram Mohan Roy Road, Aanand Towers, Bangalore, India
2Sparsh Hospital, Yeshwantpur, Bangalore, India
Introduction: Certain receptor subtypes of breast cancer are aggressive. Poor prognosis of these patients is often compounded by advanced stage at the time of diagnosis. An understanding of the relationship between risk factors associated with receptor subtypes and advanced-stage diagnosis would help in improving survival rates. In this study, we aimed to identify risk factors associated with different receptor subtypes and their relation with advanced-stage diagnosis. Methods: A prospective cohort of 539 breast cancer patients visiting a private clinic in Bengaluru was used. Associations between variables for different breast cancer receptor subtypes and advancedstage diagnosis and were derived by Odds Ratio (OR) by logistic regression and two-sided P-values <0.05 is considered significant. Results: Symptomatic diagnosis (OR-3.5 (1.9-6.4)), lower education (OR-1.9 (1.3-2.8)) and lower economic condition (OR-3.1 (2.1-4.6)) were significantly associated with advanced-stage diagnosis. Patient’s age at diagnosis >50 (OR-0.6 (0.42-0.87)), higher education (OR-1.64 (1.13-2.35)), upper economic standards (OR-1.68 (1.14-2.46)) and post-menopausal status (OR-0.64 (0.44-0.93)) were associated with HR+/HER2- disease. Pre-menopausal status (OR-1.47 (1.02-2.13)), lower education (OR-0.68 (0.47-0.98)) were associated with HER2+ disease. Age, ≤ 50 ((OR-1.7 (1.13-2.63)), lower economic status (OR-0.62 (0.40-0.95)) were associated with TNBC subtype. Symptomatic diagnosis among HR+/HER2-patients (P=0.0011), age below 50 years (P=0.02), lower education (P<0.0001) and lower economic status (P<0.0001) among HER2 + patients have shown to be risk factors for advanced-stage diagnosis in this cohort. Conclusion: Dissemination of knowledge on risk factors and imparting education especially among patients of lower economic strata can improve early-stage diagnosis of breast cancer.
Risk factors; Advanced-stage; Breast cancer; Receptor subtypes; Socio-demographic
Gunda A, Thumsi J, Natraj M, Bakre MM. Socio-Demographic Factors and Their Associations with Receptor Subtypes: Observations from a South Indian Breast Cancer Patient Cohort. Clin Surg. 2021; 6: 3257.