Clin Surg | Volume 6, Issue 1 | Case Report | Open Access

Anal Squamous Cell Carcinoma with Cystic Brain Metastases: A Case Report

Cameron David1*, Parkin Edward1 , Mitchell Peter J1 and Williamson Deborah2

Department of General Surgery, Lancashire Teaching Hospitals NHS Trust, UK 2 Department of Oncology, Lancashire Teaching Hospitals NHS Trust, UK

*Correspondance to: Cameron David 

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Anal canal cancers are a rare disease with infrequent metastasis to distant organs. When present, distant metastases are most often located in the liver or lung. As such the possibility exists for clinicians to overlook rare metastatic sites. We present the case of a 47-year-old female patient with a T3 N1c anal squamous cell carcinoma treated with radical chemo-radiotherapy. Three years following initial diagnosis neurological symptoms were reported including headache and bilateral numbness and paresthesia in the C6 & C7 distribution. Magnetic Resonance Imaging demonstrated multiple cystic metastatic lesions within the brain for which the patient underwent palliative radiotherapy. Brain metastasis from anal squamous carcinoma is exceptionally rare with only five previous cases reported in literature. Prognosis following this diagnosis is poor. To our knowledge cystic lesions have not previously been described. Clinicians treating patients with anal cancers should be aware of unlikely metastatic sites and should consider the possibility of brain metastasis in patients with risk factors for disease recurrence such as node positive disease or poorly differentiated tumors.


David C, Edward P, Mitchell Peter J, Deborah W. Anal Squamous Cell Carcinoma with Cystic Brain Metastases: A Case Report. Clin Surg. 2021; 6: 3146..

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