Clin Surg | Volume 6, Issue 1 | Case Report | Open Access

Plexiform Fibromyxoma of the Colon: A Case Report

Joshua Ellis1 , Jacob A Ukleja1 , Raul Gonzalez2 , Tiffany Yin2 , Rondell Graham3 and Thomas Cataldo4*

1 Harvard Medical School, USA 2 Department of Pathology, Beth Israel Lahey Health Medical Center, USA 3 Department of Laboratory Medicine and Pathology, Mayo Clinic, USA 4 Department of Colon and Rectum Surgery, Beth Israel Lahey Health Medical Center, Harvard Medical School, USA

*Correspondance to: Thomas Cataldo 

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Introduction: Plexiform fibromyxoma is a rare mesenchymal tumor found in the gastrointestinal tract, most commonly in the gastric antrum. Limited data exists regarding a plexiform fibromyxoma arising primarily from the colon. Case Report: We report the first case of a plexiform fibromyxoma arising from the colon in a 43 yearold male with an unremarkable past medical and surgical history. After presenting to his primary care provider with vague abdominal pain, the patient was found to have a right upper quadrant mass on imaging that was surgically resected with a laparoscopic-assisted right colectomy for presumed adenocarcinoma of the colon. However, pathology revealed that the mass was a benign plexiform fibromyxoma. Discussion: The differential diagnosis of plexiform fibromyxoma in the colon includes more common colon masses like adenocarcinoma as well as spindle cell lesions including Gastrointestinal Stromal Tumor (GIST), schwannoma, plexiform neurofibroma, leiomyoma, leiomyosarcoma, and inflammatory myofibroblastic tumor. Immunohistochemical staining and genetic testing can help differentiate these etiologies and better characterize management and prognosis. Conclusion: In a patient presenting with vague abdominal pain with imaging findings of a colonic mass, it is crucial to maintain a broad differential diagnosis. In this paper, we describe the first case of plexiform fibromyxoma arising primarily from the colon.


Plexiform fibromyxoma; Mesenchymal tumor; Spindle cells; Abnormal abdominal imaging


Ellis J, Ukleja JA, Gonzalez R, Yin T, Graham R, Cataldo T. Plexiform Fibromyxoma of the Colon: A Case Report. Clin Surg. 2021; 6: 3122..

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