Clin Surg | Volume 6, Issue 1 | Research Article | Open Access

Antibiotic Prophylaxis Decreases Surgical Site Infections after Radical Prostatectomy

Chatenet M1 , Vincendeaua S1 , Bataillon-Buf S2 , Peyronneta B1 , Verhoesta G1 , Manuntaa A1 , Guille F1 , Shariat SF3,4,5,6, Bensala K1 , Mathieu R1*

Department of Urology, Rennes University Hospital, France 2 Unit? d'Hygi?ne Hospitali?re, P?le Microorganismes, CHU Pontchaillou, Rennes, France 3 Department of Urology, Medical University Vienna, General Hospital, Vienna, Austria 4 Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA 5 Department of Urology, Weill Cornell Medical College, New York, USA 6 Karl Landsteiner Institute, Vienna, Austria

*Correspondance to: Romain Mathieu 

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Background: Routine use of Antibiotic Prophylaxis (AP) in Radical Prostatectomy (RP) is still questionable since no comparative placebo-controlled study has been conducted. The aim of the study was to describe Surgical Site Infections (SSI), identify predictive factors of SSI, and determine the role of AP in a large cohort of patients treated with RP. Methods: Laparoscopic or robot assisted RP was performed in 295 consecutive patients between January 2010 to December 2013 in a single academic institution. Patients and operative characteristics, post-operative complications and SSI were retrospectively collected. From July 2012, patients received systematic AP during the procedure. Qualitative and quantitative variables were compared by using chi2 and Student t tests. Relationships between SSI and patient or treatment parameters including use of AP were determined using univariable and multivariable regression logistic analyses. Results: 292 patients were analyzed. Median age was 62 years. 107 patients (36.6%) received AP. SSI occurred in 52 patients (17.8%). SSI were superficial incisional SSI (n=28), and organ/space SSI (n=26). No deep incisional SSI was reported. In univariable analysis, SSI was associated with a preoperative immunosuppressive therapy (HR=7.286; CI 95% = 1.185-44.761; p=0.035), post-operative complications (HR=2.545; CI 95% = 1.027-6.312; p=0.044), and use of AP (HR=0.458; CI 95% = 0.223-0.918; p=0.028). In multivariable analysis, only post-operative complications (HR=2.603; CI 95% = 1.014-6.680; p=0.047), and use of AP (HR=0.410; CI 95% = 0.198-0.847; p=0.016) remained independent predictors. Conclusion: Use of AP in RP is associated with a decrease of SSI. The impact of AP on SSI incidence should be confirmed in a comparative, prospective, controlled study


Surgical wound infection; Antibiotic prophylaxis; Predictive factors; Radical prostatectomy; Prostate cancer


Chatenet M, Vincendeaua S, BataillonBuf S, Peyronneta B, Verhoesta G, Manuntaa A, et al. Antibiotic Prophylaxis Decreases Surgical Site Infections after Radical Prostatectomy. Clin Surg. 2021; 6: 3055..

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