Negative Pressure Wound Therapy with Potential Autologous Stem Cell Therapy: The Challenge and Future of Complex Defect Healing?

Fan Yang, Xiangjun Bai, Jie Xie, Jiajun Chen, Xiaojing Dai, Yong Li and Keith Kenter

Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China
Center for Stem Cell and Regenerative Medicine, The University of Texas Health Science Center, USA
Department of Orthopaedic Surgery, Homer Stryker MD School of Medicine, Western Michigan University, USA

^*Correspondance to: Fan Yang 

 PDF  Full Text DOI: 10.25107/2474-1647.2481

Abstract

The complex wound defect always needs a long-term clinical intervention and flap coverage, because of massive soft tissue loss with continuous sepsis and poorest granulation tissue with the impair healing process. Here, we report a 22-year-old male had suffered a work-related High Voltage Electrical Burn (HVEB), result in extensive deep tissue damage (about 12% visible total body surface area burns with a 3rd to 4th degree) with abdominal wall complex defect. A series of surgical operations and medical care's had taken by the traumatic team, including Negative Pressure Wound Therapy (NPWT) with an autologous stem cell therapy, e.g., isolated from the iliac bone marrow aspirate and injection. Our results suggested that the NPWT with stem cell treatment is successful, the complex wound defect is covered in observation time and wound healing is satisfactory.

Keywords

Multiple trauma; High-voltage electrical burn; Complex wound defect; Negative pressure wound therapy; Bone marrow aspirate; Stem cell therapy

Cite the article

Yang F, Bai X, Xie J, Chen J, Dai X, Li Y, et al. Negative Pressure Wound Therapy with Potential Autologous Stem Cell Therapy: The Challenge and Future of Complex Defect Healing? Clin Surg. 2019; 4: 2481.