Clin Surg | Volume 4, Issue 1 | Research Article | Open Access

Decreased Lipid Serum Level after Pituitary Adenoma Resection

Jianmei Yang1-3, Miaoqing Zhao4, Yejun Qin4, Qiang Zhu5, Qiangxiu Wang4, Kunpeng Wu1-3, Shounan Yi6, Haitao Yuan7, Lingwei Liu1-3, Ranran Shi1-3, Yashuang Yang1-3, Ying Gong1-3, Ru Feng1-3, Sisi Luan1-3, Yizhou Zou1-3, Wenyu Jia1-3, Zhenyu Yao1-3, Liya Zhang1-3, Xiang Li1-3, Zhao He2, Xu Hou1, Ling Gao2,3,8 and Jiajun Zhao1-3*

1Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, China
2Shandong Academy of Clinical Medicine, China
3Shandong Clinical Medical Center of Endocrinology and Metabolism, China
4Department of Pathology, Shandong Provincial Hospital affiliated to Shandong University, China
5Department of Medical Service, Shandong Provincial Hospital affiliated to Shandong University, China
6University of Sydney at West mead Hospital, Australia
7Department of Cardiac Care Unit, Shandong Provincial Hospital affiliated to Shandong University, China
8Shandong Provincial Hospital affiliated to Shandong University, China

*Correspondance to: Jiajun Zhao 

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Abstract

Objective: The aim is to evaluate the relationship between pituitary adenoma and serum lipid by pre- and post-operative.Methods: A retrospective analysis based on the clinical records of patients with pituitary adenoma was performed. A total of 1095 patients were diagnosed and underwent surgery through the endoscopic transsphenoidal approach at the Shandong Provincial Hospital (Jinan, China) from July 2010 to June 2015. According to the inclusion criteria, 959 patients were included and analyzed. The fasting lipid profile was obtained in the medical records. Pituitary adenomas are classified as different types according to histological diagnoses. The proportion of serum lipid disorders in various pituitary adenomas was analyzed in pre- and post-operative.Results: Of all patients with PA, approximately 75.7% of patients exhibited dyslipidemia. Each type of tumor was positive association with the serum lipid level (pure Adrenocorticotropic Hormone (ACTH)+ adenomas > pure Follicle-Stimulating Hormone (FSH)/Luteinizing Hormone (LH)+ adenomas > chromophobic adenomas > pure prolactin (PRL)+ adenomas > pure Thyroid- Stimulating Hormone (TSH)+ adenomas > mixed pituitary adenomas > pure Growth Hormone (GH)+ adenomas). Additionally, the serum lipid level decreased after the pituitary adenoma resection. Surprisingly, lipid serum level elevated again when pituitary adenoma recurred and the serum lipid level sharp reduced again follow the second operation. Pituitary adenoma accompanied with dyslipidemia was more easily relapsed. The recurrence ratio of pituitary adenoma in the patients with dyslipidemia was high and up to 2-fold that without lipid disorders, especially TSHoma.Conclusion: There was the relationship between pituitary adenoma and dyslipidemia.

Keywords:

Pituitary; Pituitary adenomas; Resection; Recurrence; Serum lipid levels

Citation:

Yang J, Zhao M, Qin Y, Zhu Q, Wang Q, Wu K, et al. Decreased Lipid Serum Level after Pituitary Adenoma Resection. Clin Surg. 2019; 4: 2332.

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