Rosete Nogueira1-3*, Pedro Cardoso3, Ana Cristina Braga4, Cláudia Almeida3, Cristina Nogueira- Silva1,2, Jorge Correia Pinto1,2
1Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Surgical Sciences Domain, Campus de Gualtar; 4710-057, Braga, Portugal
2ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal
3CGC Genetics, Embryofetal Pathology Laboratory, 706, 1º, 4000-432, Porto, Portugal
4School of Engineering, University of Minho, Department of Production and Systems, Braga, Portugal
Introduction: The pathogenesis of Congenital Diaphragmatic Defects (CDD) is not clear. Placental factors have been implicated in the pathogenesis of congenital anomalies.Objective: To assess the placental measurements on CDD and to compare with a group of fetuses without CDD. Material and
Methods: In this retrospective cross-study, 30 placentas of fetuses with CDD sent to Embryo fetal Pathology Laboratory, Centro de Genética Clínica (CGC), Porto, was evaluated. To compare the placental parameters in CDD group, 71 placentas from fetuses without CDD, matched by Gestational Age (GA) were selected.Conclusion: Placental size and umbilical cord length and diameter have an impact on CDD.
Congenital diaphragmatic defects; Diaphragmatic agenesis; Diaphragmatic eventration; Placenta size; Umbilical cord length; Umbilical cord diameter
Nogueira R, Cardoso P, Braga AC, Almeida C, Nogueira-Silva C, Pinto JC. Morphological Placental Portraits in Congenital Diaphragmatic Defects: A Pathological Study Approach. Clin Surg. 2018; 3: 2197.