Acute Monocyte Subset Counts in Patients Undergoing Coronary Surgery

Diana M Valencia-Nuñez, Willy Kreutler, Ana Merino, Ignacio Muñoz-Carvajal, David Holzhey, Pedro Aljama, Rafael Ramirez-Chamond and Julia Carracedo- Añon D

Division of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany
DEKRA. Chemnitz.Germany
Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía/Universidad de Córdoba. Córdoba, Spain
Department of Cardiovascular Surgery. Hospital Universitario Reina Sofía.Córdoba, Spain
Department of Nephrology. Hospital Universitario Reina Sofía. Córdoba, Spain
Department of Biology Systems, Physiology, Alcala University, Alcala de Henares. Spain
Department of Genetics, Physiology, and Microbiology, Faculty of Biology, Complutense University/Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28040 Madrid, Spain

^*Correspondance to: Diana M Valencia-Nu�ez 

 PDF  Full Text DOI: 10.25107/2474-1647.2010

Abstract

Elevated proinflammatory monocyte levels may predict cardiovascular events in several diseases. The present paper reports on changes in Classical (CD14++CD16-), intermediate(CD14++CD16+) and particularly non-classical (CD14++CD16+) monocyte counts in patients undergoing coronary bypass surgery with respect both to baseline levels in healthy subjects. In an observational descriptive study, baseline counts in 31 patients scheduled for coronary revascularization surgery were compared with 25 healthy controls. In a subsequent longitudinal study in patients undergoing surgery were monitored at 5 time points up until 48 hours after surgery: biochemical markers for ischemia and acute inflammation were measured, and monocyte subset percentages were quantified by flow cytometry. Baseline and endpoint classical monocyte counts in coronary patients were significantly lower than those of healthy controls (p<0.05). Intermediate monocytes populations were significantly higher at all time points surgery group than in controls, though progressively declining over time to approach control levels. Baseline counts for the non-classical subset, widely linked to cardiovascular risk, were significantly higher in the coronary group than in controls (p<0.001) and, though falling over time, did not attain normal levels over the study period (p<0.001). Given the modulatory effect of extracorporeal circulation on biochemical parameters, a secondary analysis was performed to ascertain the potential effect of ECC on monocyte subset counts: no significant inter-group difference in counts was observed.

Keywords

Coronary disease; Monocytes; Revascularization

Cite the article

Valencia-Nu�ez DM, Kreutler W, Merino A, Mu�oz-Carvajal I, Holzhey D, Aljama P, et al. Acute Monocyte Subset Counts in Patients Undergoing Coronary Surgery. Clin Surg. 2018; 3: 2010.