Phyllodes Breast Tumors: A Review of a Single Saudi Institution Experience

Yousef Al-Alawi, Amal Alhefdhi, Badr Aldrees, Sara AlSani, Ihab Anwar, Asma Tulbah, Taher Al-Tweigeri and Osama Al-Malik

Department of Surgery, Prince Salman Armed Forces Hospital, Saudi Arabia
Department of General Surgery, King Faisal Specialist Hospital and Research Centre, Alfaisal University, Saudi Arabia
Department of General Surgery, King Faisal Specialist Hospital and Research Centre, Saudi Arabia
Department of Pathology & Laboratory Medicine, Anatomic Pathology Section, King Faisal Specialist Hospital and Research Centre, Saudi Arabia
Department of Medical Oncology, Oncology Center, King Faisal Specialist Hospital and Research Centre, Saudi Arabia

^*Correspondance to: Osama Al-Malik 

 PDF  Full Text DOI: 10.25107/2474-1647.1904

Abstract

Introduction: Phyllodes Tumors (PT) are rare fibroepithelial neoplasms, accounting for less than 0.5% of all primary breast tumors. This study aims to evaluate the local recurrence, distant metastasis, and mortality rates of PT cases.Methods: A retrospective analysis of the clinical, pathological, and therapeutic data of 45 patients with a PT who were treated between January 2000 and December 2015 at a single Saudi institution. Tumors were classified into benign (21 cases), borderline (6 cases), and malignant (18 cases) according to the criteria proposed by the World Health Organization "WHO".Results: The median follow-up period was 35 (7 months to 185 months). The median age was 37 (19 years to 62 years). The median tumor size was 9.2 (2.3 cm to 25 cm). Surgery consisted of wide local excision in 27 cases (60%), simple mastectomy in 14 cases (31.1%), and nipple-sparing mastectomy in 4 cases (8.9%). The surgical margins were positive in 12 cases (26.7%). While, the overall rate of local recurrence for the entire group was 8.9% (4 cases), it was 4.8% (1 case) for benign PT, and 16.7% (3 cases) for malignant PT. Distant metastasis developed in 6 patients with malignant PT; thus the distant metastasis rate was 13.3% for the entire group and 33.3% for the group with malignant PT. There were 2 mortality cases among those affected with malignant PT. Therefore, the mortality rate was 4.4% for the entire group and 11.1% for the group with malignant PT.Conclusion: Our experience suggests that surgery with negative margins is the treatment of choice.

Keywords

Phyllodes tumors; Breast; Benign; Malignant

Cite the article

Al-Alawi Y, Alhefdhi A, Aldrees B, AlSani S, Anwar I, Tulbah A, Al-Tweigeri T, et al. Phyllodes Breast Tumors: A Review of a Single Saudi Institution Experience. Clin Surg. 2018; 3: 1904.