Ioannis Tilaveridis1*, Ioannis Chatzistefanou1, Dimitrios Mastagkas2, Lampros Zouloumis1 and Pastelli Nikoletta3
1Department of Oral & Maxillofacial Surgery, Aristotle University of Thessaloniki, Greece
2Department of Oral & Maxillofacial Surgery, KAT Hospital, Athens, Greece
3Pathologist, Registrar, General Hospital G. Papanikolaou, Exohi, Greece
Background: We report a case of a 76-year-old woman, presented with a primary lymphoepithelial carcinoma of the parotid gland. Lymphoepithelial carcinoma (LEC) is a rare variant of undifferentiated carcinoma that accounts for less than 0.4% of all salivary gland malignancies. There is strong association with Epstein-Barr virus (EBV) infection. These tumors are histologically indistinguishable from metastatic undifferentiated nasopharyngeal carcinoma and meticulous examination of the pharynx is necessary to exclude metastatic disease and establish diagnosis. Primary surgical excision followed by adjuvant radiotherapy is the most widely accepted therapeutic approach; however, controversies still exist in the current literature regarding the proper management.Conclusion: Lymphoepithelial carcinoma is a rare tumor and beyond the differential diagnosis further studies and multiclinical trials seem necessary to effectively guide treatment decisions.
Carcinoma; Epstein-Barr virus; Lymphoepithelial; Parotid Gland
Tilaveridis I, Chatzistefanou I, Mastagkas D, Zouloumis L, Nikoletta P. Lymphoepithelial Carcinoma of the Parotid Gland: A Case Report and a Sort Review. Clin Surg. 2017; 2: 1840.