Clin Surg | Volume 2, Issue 1 | Research Article | Open Access

Reducing Infanticide in Neonatal Rodents after Surgery by Using Tissue Glue

Xinhao Zeng1, Zefeng Lin2*, Huiting Lin2, Ming Fu2, Yanlu Tong2, Hongjiao Chen2 and Qiuming He2

1Department of Pediatric Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
2Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China

*Correspondance to: Zefeng Lin 

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To establish some special animal model, neonatal rodents must be experienced surgery. However, surgical and even simple invasive procedures in pups often lead to infanticide or maternal rejection by their dam. Tissue glue has been clinically applied to close the human operated incision over four decades. In this study, we present the feasibility of tissue glue in wound’s closure and outcomes in neonatal rodent’s surgery. One hundred and thirty-two neonatal rodents in experimental group underwent ligation of the common carotid artery (CCA, n=85, small incision) and proper hepatic artery (PHA, n=47, large incision) and their wound were closed by tissue glue while 58 pups in historical control group and their incision were sutured. There were statistically significant differences in the survival rate of CCAL (98.9% vs. 65.7%, P<0.01) and PHAL (95.7% vs. 47.8%, P<0.01). Clearly, high survival rate in the experimental pups suggests that the application of tissue glue can improve the survival rate in neonatal rodent’s surgery and reduce the number of laboratory animal.


Neonatal surgery; Rodents; Infanticide; Survival; Animal welfare


Zeng X, Lin Z, Lin H, Fu M, Tong Y, Chen H, et al. Reducing Infanticide in Neonatal Rodents after Surgery by Using Tissue Glue. Clin Surg. 2017; 2: 1800.

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