Clin Surg | Volume 2, Issue 1 | Research Article | Open Access

Effects of Probiotics, Prebiotics and Symbiotics on Serum Cholesterol Levels

Sude Hatun Aktimur1, Murat Suher2, Derya Onal Darilmaz3, Recep Aktimur4* and Emre Ergül5

1Department of Hematology, Istanbul Training and Research Hospital, Istanbul, Turkey
2Department of Internal Medicine, Bozok University, Faculty of Medicine, Yozgat, Turkey
3Department of Biotechnology and Molecular Biology, Aksaray University, Faculty of Science and Arts, Aksaray, Turkey
4Department of General Surgery, Istanbul Aydin University, Faculty of Medicine, Istanbul, Turkey
5Department of General Surgery, Dr. Hulusu Alatas Elmadag State Hospital, Ankara, Turkey

*Correspondance to: Recep Aktimur 

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Abstract

Objective: The aim of this study is to analyze the impact of probiotics, prebiotics, symbiotics on lipid metabolism in hypercholesterolemia.Materials and
Methods:
A total of 30 Wistar rats were divided into 5 groups and fed the appropriate diets. Group 1 was given only normal rat chow. Group 2 were given cholesterol rich diet, group 3 were given cholesterol rich diet and probiotics, group 4 were given cholesterol rich diet and prebiotics, group 5 were given cholesterol rich diet and symbiotics for 21 days.Results: Mean values of AST in groups were 123 ± 1.1 U/l, 124 ± 1.18 U/ml, 135 ± 1 U/ml, 136 ± 0.89, 143 ± 0.78 U/ml. Mean values of ALT in groups were 72 ± 0.89 U/l, 73 ± 1, 74 ± 0.78 U/ml, 86 ± 1.1, 95 ± 0.63 U/ml. Mean values of total cholesterol in groups were 51.7 ± 0.91 mg/dl, 53.5 ± 1 mg/ dl, 45.8 ± 1 mg/dl, 45.0 ± 0.89 mg/dl, 44.4 ± 1 mg/dl. Mean values of LDL cholesterol in groups were 17.2 ± 0.77 mg/dl, 25.1 ± 0.63 mg/dl, 14.0 ± 0.63 mg/dl, 11.9 ± 0.89 mg/dl, 10.9 ± 0.89 mg/dl. Mean values of HDL cholesterol in groups were 17.8 ± 0.89 mg/dl, 11.4 ± 0.77 mg/dl, 15.9 ± 0.91 mg/dl, 17.0 ± 0.89 mg/dl, 17.5 ± 0.91 mg/dl. Mean values of triglycerids in groups were 83.6 ± 0.63 mg/dl, 85.0 ± 0.63 mg/dl, 79.6 ± 0.89 mg/dl, 80.6 ± 0.77 mg/dl, 80.1 ± 0.77 mg/dl.Conclusion: Probiotics and prebiotics improve lipid metabolism but alter AST and ALT values in rats, especially when they are used in combination.

Keywords:

Glutathion; Diabetes mellitus; Complications

Citation:

Aktimur SH, Suher M, Darilmaz DO, Aktimur R, Erg´┐Żl E. Effects of Probiotics, Prebiotics and Symbiotics on Serum Cholesterol Levels. Clin Surg. 2017; 2: 1652.

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