Effects of Probiotics, Prebiotics and Symbiotics on Serum Cholesterol Levels

Sude Hatun Aktimur, Murat Suher, Derya Onal Darilmaz, Recep Aktimur and Emre Ergül

Department of Hematology, Istanbul Training and Research Hospital, Istanbul, Turkey
Department of Internal Medicine, Bozok University, Faculty of Medicine, Yozgat, Turkey
Department of Biotechnology and Molecular Biology, Aksaray University, Faculty of Science and Arts, Aksaray, Turkey
Department of General Surgery, Istanbul Aydin University, Faculty of Medicine, Istanbul, Turkey
Department of General Surgery, Dr. Hulusu Alatas Elmadag State Hospital, Ankara, Turkey

^*Correspondance to: Recep Aktimur 

 PDF  Full Text DOI: 10.25107/2474-1647.1652

Abstract

Objective: The aim of this study is to analyze the impact of probiotics, prebiotics, symbiotics on lipid metabolism in hypercholesterolemia.Materials and
Methods: A total of 30 Wistar rats were divided into 5 groups and fed the appropriate diets. Group 1 was given only normal rat chow. Group 2 were given cholesterol rich diet, group 3 were given cholesterol rich diet and probiotics, group 4 were given cholesterol rich diet and prebiotics, group 5 were given cholesterol rich diet and symbiotics for 21 days.Results: Mean values of AST in groups were 123 ± 1.1 U/l, 124 ± 1.18 U/ml, 135 ± 1 U/ml, 136 ± 0.89, 143 ± 0.78 U/ml. Mean values of ALT in groups were 72 ± 0.89 U/l, 73 ± 1, 74 ± 0.78 U/ml, 86 ± 1.1, 95 ± 0.63 U/ml. Mean values of total cholesterol in groups were 51.7 ± 0.91 mg/dl, 53.5 ± 1 mg/ dl, 45.8 ± 1 mg/dl, 45.0 ± 0.89 mg/dl, 44.4 ± 1 mg/dl. Mean values of LDL cholesterol in groups were 17.2 ± 0.77 mg/dl, 25.1 ± 0.63 mg/dl, 14.0 ± 0.63 mg/dl, 11.9 ± 0.89 mg/dl, 10.9 ± 0.89 mg/dl. Mean values of HDL cholesterol in groups were 17.8 ± 0.89 mg/dl, 11.4 ± 0.77 mg/dl, 15.9 ± 0.91 mg/dl, 17.0 ± 0.89 mg/dl, 17.5 ± 0.91 mg/dl. Mean values of triglycerids in groups were 83.6 ± 0.63 mg/dl, 85.0 ± 0.63 mg/dl, 79.6 ± 0.89 mg/dl, 80.6 ± 0.77 mg/dl, 80.1 ± 0.77 mg/dl.Conclusion: Probiotics and prebiotics improve lipid metabolism but alter AST and ALT values in rats, especially when they are used in combination.

Keywords

Glutathion; Diabetes mellitus; Complications

Cite the article

Aktimur SH, Suher M, Darilmaz DO, Aktimur R, Erg�l E. Effects of Probiotics, Prebiotics and Symbiotics on Serum Cholesterol Levels. Clin Surg. 2017; 2: 1652.