Shingo Hirao, Hidetoshi Masumoto* and Kenji Minatoya
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, JapanFulltext PDF
Cardiopulmonary bypass (CPB) has been an essential modality in cardiovascular surgery. Although the technique has since undergone dramatic refinement, prolonged CPB-related multi-organ complications due to contact activation, ischemia–reperfusion injury, coagulation, endotoxemia and/or production of oxygen free radicals still compromise the outcome of cardiovascular surgeries. Animal models recapitulating the clinical usage of CPB help elucidate the pathophysiological processes following CPB, and aid in the development of strategies aimed at preventing these complications. Rat CPB models mimicking clinical situations in cardiovascular surgery have been refined and have gradually taken the place of large-animal models because of greater costeffectiveness, convenient experimental processes, abundant testing methods at the genetic or protein levels, and genetic consistency. In the present review, we discuss various beneficial aspects of rat CPB models for investigating CPB-related multi-organ injury and for mitigating the severity of complications in an organ-specific manner (lung/kidney/brain/liver/myocardium/intestine). The interventions established through basic research using rat CPB models may further improve the safety of cardiovascular surgery in the future.
Rat cardiopulmonary bypass; Multi-organ injury; Kidney
Hirao S, Masumoto H, Minatoya K. Rat Cardiopulmonary Bypass Models to Investigate Multi-Organ Injury. Clin Surg. 2017; 2: 1509.