Gordon H. Sasaki*
Department of Plastic Surgery, Loma Linda Medical University, USAFulltext PDF
Embryological development of a hair follicle and its cyclical adult transformation reside in quiescent niches arranged in epidermal, mesenchymal and neruroectodermal stem cell habitats that interface with each other in a hierarchical manner by cross-talking signals throughout its morphological life cycling. These compartmental growth centers trigger through their stimulating and inhibiting molecules either the induction or retardation of architectural layers and structures for de novo or post-natal follicles. Recent evidence for extrinsic regulation by transcriptional-growth factor activity by adipocytes and platelet-rich plasma for follicle development and cycling has provided potential therapeutic avenues for follicular regeneration. This review will focus on the behavior of follicular cells that play dominant roles in the development of androgenetic alopecia and chronic telogen effluvium. It is hoped that the discussed evidence-base treatment approaches may evolve into FDAapproved therapy to address hair loss and its rejuvenation for millions of men and woman.
Sasaki GH. Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons. Clin Surg. 2016; 1: 1257.