Department of General Surgery, Ondokuz Mayis University School of Medicine, TurkeyFulltext PDF
It has been suggested that they a gene-expression-classifier (GEC) would be worth to be used if there is low suspicion for thyroid cancer in patients with atypia of undetermined significance / follicular lesion of undetermined significance (AUS/FLUS).In our recent study among 153 patients with AUS/FLUS who underwent surgery, malignancy rate for nodules without any worrisome ultrasound features (low suspicion category) was 0%. GEC test had a false negative rate (FNR) of 5.5% for AUS/FLUS patients, and 43% of AUS/FLUS patients have been assumed to be benign on GEC. If GEC was performed on AUS/FLUS patients with low suspicion category (35 patients) in our series, the volume of thyroidectomy would be reduced from 153 to 138 resulting in a 10% decrease with a FNR of 5.5%. If AUS/FLUS nodules with low suspicion category would not have undergone surgery, thyroidectomy volume would be reduced from 153 to 118 resulting in a 23% decrease with a FNR of 0%. These findings show that our approach has apparent advantage over the use of GEC.
Kuru B. Clinical Decision Making for Surgery using Ultrasound Characteristics of the Thyroid Nodules Classified as Category III (AUS/FLUS) in the Era of Molecular Tests. Clin Surg.2016; 1: 1031.